with or without ayahuasca

Sting took it with Trudie.
Anthropologists have taken it and written about it.
And I'm not sure why I have been thinking about it.
I think it has to do with this question:
Can a radical transformation of consciousness happen without ayahuasca?
Can it happen over time? Can it happen in meditation?
in prolonged phenomenological meditation over one topic?

I suspect the answer is yes because this has been my experience.

When I read the accounts about the aftermath of the ayahuasca experience, the radical shift in consciousness seems to have as much to do with one's previous state of consciousness: split, repressed, alienated, etc. So if one is still indigenous at the core, it is possible that one is closer to the reality of 'sacred wholeness' with or without ayahuasca. yah?

Still I remain curious.